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A Comparison of the Progression Rate to Acquired Immunodeficiency Syndrome between Intravenous Drug Users and Homosexual Men

Anne Eskild, Department of Epidemiology, National Institute of Public Health, Oslo, Norway, Correspondence and offprints to: Anne Eskild Department of Epidemiology National Institute of Public Health Geitmyrsveien 75 0462 Oslo 4 Norway

Per Magnus

Per Magnus, Department of Epidemiology, National Institute of Public Health, Oslo, Norway

Christian Sohlberg

Christian Sohlberg, Department of AIDS Prevention, Oslo City Department of Health and Environment, Norway

Finn Jensen

Finn Jensen, Department of AIDS Prevention, Oslo City Department of Health and Environment, Norway

Peter Kittelsen

Peter Kittelsen, Department of AIDS Prevention, Oslo City Department of Health and Environment, Norway

In order to study differences in progression to Acquired Immunodeficiency Syndrome (AIDS) between risk groups, 205 homosexual men and 185 intravenous drug users (IVDUs) were followed from diagnosed seropositivity for Human Immunodeficiency Virus Type-1 (HIV) for a mean period of 46 months (range 1–88 months). Seven (4%) IVDUs and 55 homosexual men (27%) were diagnosed with AIDS during the follow-up period. The probability of being AIDS-free four years after diagnosed HIV positivity was 0.96 for IVDUs (SE 0.02) and 0.73 (SE 0.04) for homosexual men (p < 0.001, log rank test). When controlling for age and gender, the relative risk of AIDS progression for homosexual men was 9.1 (3.5–24.1, 95% confidence interval) as compared with IVDUs. Even when 24 months of follow-up time without progression were added for all homosexual men, assuming that the epidemic started two years earlier in this group, the relative risk of progression was 5.4 (2.1–14.4, 95% confidence interval) for homosexual men.

Key Words: HIV • AIDS • intravenous drug users • homosexual men • progression • epidemiology

Scandinavian Journal of Public Health, Vol. 22, No. 4, 309-314 (1994)
DOI: 10.1177/140349489402200411


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