This Article Full Text (PDF) A correction has been published All Versions of this Article: 1403494808101373v1 37/4/434    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Scopus Google Scholar Articles by Lindahl, B. Articles by Jansson, J.-H. PubMed PubMed Citation Articles by Lindahl, B. Articles by Jansson, J.-H. Social Bookmarking                         What's this?

A randomized lifestyle intervention with 5-year follow-up in subjects with impaired glucose tolerance: Pronounced short-term impact but long-term adherence problems

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, bernt.lindahl{at}medicin.umu.se

Torbjörn K. Nilssön

Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden

Knut Borch-Johnsen

Steno Diabetes Centre, Gentofte, Denmark

Michael E. Røder

Department of Cardiology and Endocrinology, Nordsjaellands Hospital Hillerød, Hillerød, Denmark

Stefan Söderberg

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Lars Widman

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Owe Johnson

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Göran Hallmans

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Jan-Håkan Jansson

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Aims: To compare data on cardiovascular risk factor changes in lipids, insulin, proinsulin, fibrinolysis, leptin and C-reactive protein, and on diabetes incidence, in relation to changes in lifestyle. Methods: The study was a randomized lifestyle intervention trial conducted in northern Sweden between 1995 and 2000, in 168 individuals with impaired glucose tolerance (IGT) and body mass index above 27 at start. The intensive intervention group (n = 83) was subjected to a 1-month residential lifestyle programme. The usual care group (n = 85) participated in a health examination ending with a single counselling session. Follow-up was conducted at 1, 3 and 5 years. Results: At 1-year follow-up, an extensive cardio-metabolic risk factor reduction was demonstrated in the intensive intervention group, along with a 70% decrease of progress to type 2 diabetes. At 5-year follow-up, most of these beneficial effects had disappeared. Reported physical activity and fibre intake as well as high-density lipoprotein cholesterol were still increased, and fasting insulin and proinsulin were lower. Conclusions: The intervention affected several important cardio-metabolic risk variables beneficially, and reduced the risk for type 2 diabetes, but the effects persisted only as long as the new lifestyle was maintained. Increased physical activity seemed to be the behaviour that was most easy to preserve.

Key Words: Cardiovascular risk factors • diabetes mellitus • diet • intervention • physical activity

This version was published on June 1, 2009

Scandinavian Journal of Public Health, Vol. 37, No. 4, 434-442 (2009)
DOI: 10.1177/1403494808101373


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Bo, R. Gambino, G. Ciccone, R. Rosato, N. Milanesio, P. Villois, G. Pagano, M. Cassader, L. Gentile, M. Durazzo, et al. Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention Am. J. Clinical Nutrition, December 1, 2009; 90(6): 1502 - 1508. [Abstract] [Full Text] [PDF]