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Apolipoprotein E genotypes and their relation to lipid levels in a rural South African population 1

Department of Medical Science, University of Limpopo, South Africa

Marianne Alberts

Department of Medical Science, University of Limpopo, South Africa, ma15{at}pixie.co.za, mariannea{at}ul.ac.za

Petter Urdal

Department of Clinical Chemistry, Ullevaal Hospital, Oslo, Norway

Aims: Genetic variation at the apolipoprotein E (apoE) locus is an important determinant of plasma lipids. The aim of the present study was to evaluate the association between apolipoprotein E genotype and plasma lipid levels among a rural black population in South Africa. Methods: Lipid levels and apoE genotypes were studied in 505 volunteer subjects (363 women, 142 men) resident in the Dikgale demographic surveillance site. Results: Allele frequencies were found to be 0.190 for 2, 0.518 for 3, and 0.293 for 4, indicating a relatively low frequency of the 3 allele and a high frequency of the 4 allele. To determine the effect of apoE polymorphism on lipid levels three groups were formed: namely 2-, 3-, and 4-expressing groups. A significant effect of the apoE genotype on total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)/Total cholesterol (TC) ratio, and triglycerides was observed. LDL-C was significantly lower and the HDL-C/TC ratio was significantly higher in the 2 group compared with the 3 and 4 groups. Triglyceride levels were significantly higher in the 2 group than in the 3 group. Conclusions: With the unfavourable apoE allele distribution, and the lifestyle changes taking place in rural South African populations, preventive strategies need to be developed to limit a potential epidemic of cardiovascular disease in the black population of South Africa.

Key Words: Apolipoprotein E genotypes • ethnicity • gender • lipid levels • rural population

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Scandinavian Journal of Public Health, Vol. 35, No. 69 suppl, 60-65 (2007)
DOI: 10.1080/14034950701355635


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Masemola, M. L. Articles by Urdal, P. Search for Related Content PubMed Articles by Masemola, M. L. Articles by Urdal, P. Social Bookmarking                         What's this?